Premium
P3‐350: ASSOCIATION OF FDG UPTAKE AND RS‐FMRI–BASED EIGENVECTOR CENTRALITY IN COGNITIVE IMPAIRMENT
Author(s) -
Apostolova Ivayla,
Nierhaus Till,
Lange Catharina,
Suppa Per,
Spies Lothar,
Mester Janos,
Klutmann Susanne,
Adam Gerhard,
Fiebach Jochen B.,
Buchert Ralph
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1711
Subject(s) - voxel , white matter , nuclear medicine , resting state fmri , medicine , statistical parametric mapping , partial volume , spatial normalization , grey matter , neuroscience , psychology , magnetic resonance imaging , radiology
between two sides in PA scores (p1⁄40.52). The 90 percentile cut-off of the age-specific distribution increased from 0 (at age 20-29) to 1 (at age 30-59) and then up to 2 for subjects over 60s (Figure). No significant difference was observed between APOε4 carriers and non-carriers, neither in the whole sample (p1⁄40.23 right; p1⁄40.28 left), nor in the subsets over 60 (p1⁄40.55 right; p1⁄40.61 left). Conclusions:This study provides the first normative values for PA in the general population. According to the literature, our data suggest the need to define age specific thresholds for normality in clinical assessments. References: Koedam E L G E et al. Visual assessment of posterior atrophy development of a MRI rating scale. Eur Radiol. 2011; 21:2618-2625. Galluzzi S et al. The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions. Aging Clin Exp Res. 2009; 21(4-5):266-276.