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P3‐327: NEUROPSYCHIATRIC SYMPTOMS IN AT‐RISK GROUPS FOR AD DEMENTIA AND THEIR RELATION TO AD BIOMARKERS: DATA FROM THE DELCODE STUDY
Author(s) -
Sannemann Lena,
Hu Xiaochen,
Spottke Annika,
Brosseron Frederic,
Buerger Katharina,
Fliessbach Klaus,
Heneka Michael,
Kilimann Ingo,
Laske Christoph,
Peters Oliver,
Priller Josef,
Schneider Anja,
Teipel Stefan J.,
Wiltfang Jens,
Wagner Michael,
Düzel Emrah,
Jessen Frank
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1688
Subject(s) - dementia , medicine , cognitive impairment , disease , cognition , cognitive decline , alzheimer's disease , oncology , psychiatry , gastroenterology
executive functioning and cognitive flexibility depended on ESR1 Pvu II polymorphism. Processing speed was better in women being TT homozygotes than in women with TC and CC genotypes. Executive functioning and cognitive flexibility were lower in women with TT genotype than in those with TC and CC genotypes. Memory, verbal memory, visual memory and processing speed depended on ESR1 XbaI. AA and AG genotypes was linked to better function in those domains than GG homozygotes. NCI and six cognitive functions differed between genotypes of PvuII and XbaI combined. Presence of CC PvuII and GG XbaI was linked to the lowest cognitive performance Carriers of TCAA, or CC -AG – demonstrated the highest, while TT AA, or TC -AG – with moderate levels of cognitive function. Conclusions: ESR1 (PvuII and XbaI) polymorphisms influences cognitive performance in postmenopausal women NCI, memory, verbal memory, processing speed, psychomotor speed as well as reaction time were noticed to be decreased in postmenopausal women, who simultaneously carried the CC PvuII and GG XbaI genotypes.