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P3‐227: EVALUATION OF BUCHE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE
Author(s) -
Santos Gustavo A.A.,
Pardi Paulo Celso
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1586
Subject(s) - butyrylcholinesterase , acetylcholinesterase , rivastigmine , cholinesterase , aché , medicine , disease , drug , gastroenterology , endocrinology , pharmacology , enzyme , chemistry , donepezil , biochemistry , dementia
prevalence of IR was about 16%. Subjects above and below the cutoff values for IR (2.9 for HOMA-IR and 1.7 for HOMA2) did not show significant differences in terms of cerebral glucose metabolism, cognitive measures and demographic characteristics. No significant correlation was observed between peripheral IR calculated by either HOMA-IR or HOMA2 and rCMRGlc or ROI uptake of [18F]FDG. Conclusions: In this study of non-diabetic AD population with invasive measurement of cerebral glucose metabolic rate, we have demonstrated that peripheral insulin resistance does not correlate with cerebral glucose metabolism and thus it does not represent a good measure of central insulin resistance.