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P3‐210: CARDIOVASCULAR FUNCTION IS COMPROMISED IN APP/PSEN1 MICE COMPARED TO AGE‐MATCHED WILDTYPE MICE
Author(s) -
Kresge Hailey A.,
Cambronero Francis E.,
Montgomery Meghan L.,
Nackenoff Alex,
Boyd Kelli L.,
Schrag Matthew S.,
Harrison Fiona E.,
Jefferson Angela L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1569
Subject(s) - medicine , wild type , endocrinology , diastole , genetically modified mouse , cardiology , chemistry , transgene , blood pressure , mutant , gene , biochemistry
Body weight (BW) (g) 452 6 10 715 ± 22 ## 754 ± 24 ## 329 ± 7 ** 465 ± 7 ** ## 470 ± 8 ** ## Aortic wall collagen (%) 8.0 6 1.2 8.5 6 1.3 9.6 6 0.7 12.1 6 2.3 17.7 ± 0.7 ** # 20.8 ± 1.7 ** MWM, time spent to find a platform (sec) 17 6 4 18 6 4 19 6 2 16 6 2 24 6 3 31 ± 1 * ## OFT, total distance traveled day 1 first 5 mins (m) 6.7 6 0.4 3.9 ± 0.4 ## 6.9 6 0.3 5.2 ± 0.3 ## OFT, vertical activity day 1 first 5 mins (n) 329 6 25 106 ± 13 ## 345 6 15 229 ± 29 ** ##