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P2‐487: EXPLORING THE INSULA IN EARLY DEMENTIA WITH LEWY BODIES
Author(s) -
Philippi Nathalie,
Noblet Vincent,
Hamdaoui Malik,
Ehrhard Emmanuelle,
Botzung Anne,
Constans-Erbs Morgane,
Kemp Jennifer,
Monjoin Laetitia,
Albasser Timothee,
Bilger Mathias,
Soulier David,
Demuynck Catherine,
Martin-Hunyadi Catherine,
Cretin Benjamin,
Blanc Frederic
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1180
Subject(s) - insula , disgust , dementia with lewy bodies , psychology , audiology , voxel , precuneus , cognition , cognitive psychology , neuroscience , dementia , clinical psychology , medicine , pathology , radiology , disease , anger
scenarios (e.g., kitchen), each presented for 3 seconds, with an inter-stimulus interval of 500ms. SI was implemented by presenting a different number of scenes from each category (i.e., 24, 12, 6, 1). The participants were asked to verbally recognize the presented scenes in a 2 Alternative Force Choice (old/new) with both scenes belonging to the same semantic category. All participants had a performance significantly above chance under a binomial test, and no less than 60% per cent. Results:Figure 1 reports the d-prime scores for both groups. Older adults can recognize a high number of scenes and their performance is influenced by SI. The two groups differed in overall performance, as expected. However, the decrement in performance as a function of the degree of SI is not different. Conclusions: These findings show that the capacity of visual long-term memory is influenced by SI also in older participants. People with aMCI had difficulties in this memory task, which resulted in several (N 24) being excluded because their performance was at chance. The visual memory deficit of the aMCI group could be accounted for primarily by acquisition impairment as the degree of SI was independent from their baseline performance. This counterintuitive result revives the debate about the need for a theory of forgetting. This observation is preliminary given the small sample size, and calls for replication.