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P2‐340: SUBSYNDROMAL DEPRESSION INTERACTS WITH AMYLOID TO PREDICT HYPOMETABOLISM AND CONSEQUENTLY COGNITIVE DECLINE
Author(s) -
Yatawara Chathuri,
Ng Kok Pin,
Kandiah Nagaendran
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1030
Subject(s) - cognitive decline , depression (economics) , medicine , dementia , amyloid (mycology) , neuropsychology , amyloidosis , geriatric depression scale , psychology , biomarker , cognition , oncology , disease , psychiatry , depressive symptoms , pathology , biology , biochemistry , economics , macroeconomics
GLOBAL COGNITION MMSE % Decline 16.9 20.0 .420 .272 % No change 61.0 63.1 .479 .724 % Improvement 22.0 16.9 .311 .505 MoCA % Decline 28.8 22.2 .265 .987 % No change 42.4 50.8 .227 .847 % Improvement 28.8 27.0 .490 .814 EPISODIC MEMORY ADAS Delayed Word Recall % Decline 35.6 32.3 .422 .550 % No change 27.1 40.3 .090 .381 % Improvement 37.3 27.4 .167 .768 ATTENTION Color Trails Test 1 % Decline 6.9 8.2 .532 .472 % No change 89.7 85.2 .328 .324 % Improvement 3.4 6.6 .364 .539 ADAS Immediate Word Recall % Decline 29.3 16.4 .072 .039 % No change 31.0 26.2 .353 .588 % Improvement 39.7 57.4 .404 .022 Digit Span Forward % Decline 13.8 31.7 .018 .088 % No change 56.9 45.0 .134 .262 % Improvement 29.3 23.3 .299 .709 WORKING MEMORY Digit Span Backward % Decline 22.4 31.7 .178 .268 % No change 50.0 56.7 .294 .778 % Improvement 27.6 11.7 .025 .096 EXECUTIVE FUNCTION Frontal Assessment Battery % Decline 12.1 14.1 .479 .331 % No change 79.3 70.3 .176 .038 % Improvement 8.6 15.6 .184 .085 Color Trails Test 2 % Decline 5.3 11.9 .175 .043 % No change 91.2 83.1 .150 .055 % Improvement 3.5 5.1 .516 .683 Sunderland Clock % Decline 10.6 20.3 .134 .346 % No change 70.2 60.9 .209 .697 % Improvement 19.1 18.8 .573 .685 LANGUAGE Verbal Fluency (Fruits) % Decline 12.5 11.3 .537 .637 % No change 77.1 82.3 .331 .474 % Improvement 10.4 6.5 .341 .619