Premium
[F4–01–01]: PET AND MRI STUDIES IN ATYPICAL VARIANTS OF ALZHEIMER's DISEASE
Author(s) -
Ossenkoppele Rik
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.374
Subject(s) - precuneus , posterior cortical atrophy , neuroscience , primary progressive aphasia , posterior cingulate , neurodegeneration , temporal lobe , positron emission tomography , psychology , medicine , cortex (anatomy) , pathology , disease , cognition , dementia , frontotemporal dementia , epilepsy
Here, we studied the cognitive and emotional effectiveness of caregiver-implemented musical activities in persons with mild-moderate dementia (PWDs). Methods: In a three-arm randomized controlled trial (RCT), 89 PWD-caregiver dyads received a 10week singing intervention, a 10-week music listening intervention, or a usual care. Outcomewas assessed with neuropsychological tests and questionnaires on mood, quality of life (QOL) and caregiver burden at baseline, after the intervention (3-month stage, n 1⁄4 84), and 6 months later (9-month stage, n 1⁄4 74). Results:Compared to usual care, both singing and music listening enhanced general cognition and executive function and reduced depression at 3 months and enhanced orientation and autobiographical memory at 9 months. Singing also enhanced working memory at 3 months as well as reduced caregiver burden at 9 months. The positive effects of singing on working memory and of both musical activities on mood were larger in mild vs. moderate dementia. The musical background of the PWD did not influence the efficacy of the music interventions. Conclusions:PWD-caregivermusical activities have long-term cognitive, emotional, and social benefits in PWDs and could potentially be widely used in dementia care and rehabilitation.