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[P2–091]: LEAD DESIGN FOR CLASSICAL AUTOIMMUNE REACTION OF NEUROMYELITIS OPTICA SPECTRUM DISORDERS
Author(s) -
Hao Meng,
Chenling Pan,
Qun Wan,
Yong Zhao,
Xu Jun
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.740
Subject(s) - neuromyelitis optica , chemistry , mutant , mutation , molecular dynamics , antibody , medicine , immunology , biochemistry , computational chemistry , gene
large standardized dominance weights for IL-17a, interferongamma, IL-l2, and VEGF in CSF, as well IL-4 in serum. Conclusions: Inflammatory proteins have been widely documented in the AD brain. The results of the current study suggest that changes in BBB function resulting in altered permeability and transport are related to expression of specific inflammatory proteins, and that the shifting distribution of these proteins from serum to CSF in AD and MCI is correlated with more severe perturbations in BBB function.