[IC‐P‐182]: SUCCESSFUL REDUCTION OF OFF‐TARGET BINDING OF QUINOLINE DERIVATIVES AS TAU‐SELECTIVE PET TRACERS

and PACC were significantly associated in high-PiB (baseline: p1⁄40.043, baseline-to-change: p1⁄40.011, change-to-change: p1⁄40.005), but not in low-PiB individuals (all p>0.40). A marginal associationwas nevertheless observed in the low-PiB participants between change in cognition and change in tau in the voxels with elevated tau signal at baseline (Fig.5; Est.1⁄4-0.5160.28, p1⁄40.075). Conclusions: Cognitive decline in CN is associated with temporal tau accumulation, beyond the association with baseline tau. TauPET signal changes faster than cognition, which makes it a promising marker to track disease progression. Using voxel-based thresholds helps detect early tau accumulation, which may have an impact on cognition before amyloidosis is evident on PET, but this requires further studies, in larger samples with longer follow-up durations.