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[P4–365]: USING MULTI‐TRAJECTORY ANALYSIS TO INVESTIGATE DIET AND COGNITIVE CHANGE: AN MRC DEMENTIAS PLATFORM U.K. (DPUK) SUPPORTED STUDY
Author(s) -
Piumatti Giovanni,
Gallacher John
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2236
Subject(s) - dementia , cognition , cognitive decline , micronutrient , medicine , cognitive test , gerontology , population , effects of sleep deprivation on cognitive performance , demography , environmental health , psychiatry , pathology , sociology , disease
be highly effective for reversing most modifiable, lifestylerelated risk factors of LOAD, including associated comorbidities. These factors include cardiovascular disease, type 2 diabetes, hypertension, obesity, depression, hypercholesterolemia, elevated saturated fats, hyperhomocysteinemia, low vitamin levels (B6, folate, A, C, E), and elevated levels of inflammatory markers. Specific anti-inflammatory plant-derived foods were also found to promote better memory and/or cognition, including curcumin/tumeric, cumin seeds, omega-3, water hyssop, and gingko biloba. Multiple prospective and retrospective cohort studies also show that plant-based foods reduce dementia risk by a statistically significant level. Conclusions:Neurovascular inflammation and metabolic dysregulation driven mainly by poor diets likely serve as an essential underlying etiology of LOAD. Human clinical trial evidence of plant-based diets for eliminating comorbidities and risk factors of LOAD support its potential as a powerful prevention strategy. In particular, plant-based diets as well as a number of anti-inflammatory nutrients or plant-based foods have been shown to reverse cognitive deficits in clinical trials or protect against LOAD in epidemiological studies. Hence, we recommend testing of the efficacy of plant-based diets together with specific plant-based supplements in preventing or reversing LOAD in randomized controlled trials. numbers (percentages) unless stated otherwise