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[P3–316]: PRE‐CLINICAL CHARACTERIZATION OF THE NOVEL TAU PET LIGAND [18F]‐JNJ'067
Author(s) -
Kolb Hartmuth C.,
Bottelbergs Astrid,
Moechars Diederik,
Declercq Lieven,
Bormans Guy,
Rombouts Frederik
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1531
Subject(s) - microsome , human brain , ligand (biochemistry) , in vitro , chemistry , metabolite , in vivo , pathology , microbiology and biotechnology , biochemistry , biology , medicine , receptor , neuroscience
widespread reduction in CVR, with the exception of occipital CVR. Results support the notion that older adults with cognitive impairment may experience an altered cerebrovascular state in which compensatory dilation relates to CBF in areas at elevated risk and further relates to diminished CVR in anterior regions. These results provide novel insight into intracranial structural-functional relations that cannot be explained by shared systemic vascular risk factors or advancing age.