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[P3–198]: PREDICTION PERFORMANCE OF ALPHA‐SYNUCLEIN PROTEIN IN PRECLINICAL SUBJECTIVE MEMORY COMPLAINERS STRATIFIED BY AD BIOMARKERS: THE INSIGHT‐PRE AD STUDY
Author(s) -
Bun René,
Baldacci Filippo,
Toschi Nicola,
Lista Simone,
Cavedo Enrica,
Blennow Kaj,
Zetterberg Henrik,
Floris Roberto,
Garaci Francesco,
Bonuccelli Ubaldo,
Lamari Foudil,
Habert MarieOdile,
Dubois Bruno,
Hampel Harald
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1410
Subject(s) - cerebrospinal fluid , alpha synuclein , biomarker , cohort , pathophysiology , neurodegeneration , medicine , asymptomatic , memory clinic , oncology , amyloid beta , translocator protein , amyloid (mycology) , pathology , disease , parkinson's disease , cognitive impairment , neuroinflammation , biology , biochemistry
with the results of the neurochemical dementia diagnostics (NDD) biomarkers in all cases (Ab1-42, Ab42/40 ratio (IBL International), Tau, and pTau181 (Fujirebio Europe, Ghent, Belgium)). Results: Intra-assay coefficients of variation were 1.2% and 0.8% for two CSF control samples (eight repetitions of each, sample dilution 1:2). Compared to the non-demented Controls (82.76 6.0 pg/mL), MCI-AD subjects and ADD patients had significantly increased concentrations of the CSF toxic Ab oligomers (88.4 6 4.5 pg/mL, p1⁄40.027, and 88.9 6 3.7 pg/mL, p1⁄40.016, respectively); there was no significant differences between MCI-AD and ADD subjects (p>0.9). The results remained significant after adjusting for age and sex of the subjects. Neither age nor sex (either unadjusted or adjusted for the concentrations of oligomeric Ab) significantly influenced the concentrations of oligomeric Ab. Conclusions: In line with amyloid hypothesis of AD, the results of this pilot study suggest increased concentrations of oligomeric Ab in the CSF of AD patients, already at the stage of MCI. Further studies are necessary to confirm our findings.