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O3‐06‐01: Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease
Author(s) -
Kimbrough Ian,
Robel Stefanie,
Roberson Erik,
Sontheimer Harald
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.267
Subject(s) - astrocyte , ex vivo , pathology , vascular smooth muscle , pericyte , in vivo , blood vessel , amyloid (mycology) , biology , chemistry , neuroscience , medicine , endothelial stem cell , endocrinology , central nervous system , in vitro , microbiology and biotechnology , smooth muscle , biochemistry
was associated with AD (p1⁄49E-4). We then examined overlapping SNPs in adults with DS, and found rs2378991 to be associated with AD as well as age at onset (p1⁄40.04). Lastly, hippocampal neuron survival assay showed that knocking down CUGBP2 protects neurons from Ab toxicity. Conclusions: Our multi-stage study showed that genetic factors in CUGBP2 are likely to be involved in AD, and may work through the amyloid pathway.