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P4‐120: PET amyloid binding in the anterior cingulate is related to incipient episodic memory changes in preclinical Alzheimer's disease
Author(s) -
Lim YenYing,
Maruff Paul,
Noto Richard B.,
Snyder Peter J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1826
Subject(s) - neocortex , episodic memory , anterior cingulate cortex , psychology , precuneus , neuroscience , cingulate cortex , cognition , medicine , central nervous system
and total verbal intrusions. The perforant pathway, a memory pathway involving several anatomical structures of the limbic system, overlaps with the primary olfactory cortex (POC) and hippocampus. We suggest that deficits in higher level sensory processing may be indicative of pathology and neurodegeneration in normal aging but, more importantly, early stages of AD pathology. Ongoing pathological changes in the POC and hippocampus could be an underlying biological mechanism that explains the correlation of olfactory function with early cognitive symptoms.