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P3‐154: Diffusion tensor imaging detected neurodegeneration in preclinical Alzheimer disease
Author(s) -
Wang Qing,
Wang Yong,
Shimony Joshua S.,
Fagan Anne M.,
Cairns Nigel J.,
Ances Beau,
Morris John C.,
Benzinger Tammie L.S.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1525
Subject(s) - fractional anisotropy , diffusion mri , white matter , medicine , neurodegeneration , neuroscience , dementia , pathology , psychology , disease , magnetic resonance imaging , radiology
expresion in individual subjects correlated significantly with amyloid b42 /p-tau (R 1⁄40.16, p1⁄40.001; Figure 3). Conclusions:ADRP has shown to be a reliable metabolic biomarker of AD as its expression significantly differentiates cognitively impaired patients from normal subjects. Correlation of ADRP expression with CSF biomarker indicates that this metabolic biomarker is a sensitive measure of Alzheimer’s pathology in individual patients with early cognitive decline. P3-153 CORTICALAUDITORYEVOKEDRESPONSESAND MILD COGNITIVE IMPAIRMENT