Premium
P4‐132: WHITE MATTER ABNORMALITIES AND STRUCTURAL PARIETAL DISCONNECTIONS IN ALZHEIMER'S DISEASE
Author(s) -
Schilling Lucas Porcello,
Zimmer Eduardo Rigon,
Leuzy Antoine,
Benedet Andrea Lessa,
Pascoal Tharick,
Mohades Sara,
Mathotaarachch Sulantha,
Cheewakriengkrai Laksanun,
Shin Monica,
Parent Maxime,
Kang Min Su,
Manitsirikul Sarinporn,
Farajat Daliah,
Wang Seqian,
Di Ciero Jessica,
Beaudry Thomas,
Eskildsen Simon,
Rowley Jared,
Carbonell Felix,
Fonov Vladmir,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1648
Subject(s) - supramarginal gyrus , fractional anisotropy , parietal lobe , angular gyrus , white matter , temporal lobe , superior frontal gyrus , psychology , neuroscience , diffusion mri , posterior parietal cortex , middle frontal gyrus , medicine , magnetic resonance imaging , radiology , cognition , epilepsy , functional magnetic resonance imaging
Figure 1. Top: The top left pair of images shows axial views of baseline and followup scans for one subject. The difference images highlight the result using affine, mono-modal non-linear and multi-model non-linear registration. It can be noticed that using the proposed multi-model scheme, the differences in T1w intensity are still captured while better capturing the white matter tract miss-alignment. Bottom shows the significant statistical differences in rate of volume change between the fAD and the control subjects. These TBM maps have been generated using T1w images only (top) and the proposed multi-modal approach (bottom). Lucas Porcello Schilling, Eduardo Rigon Zimmer, Antoine Leuzy, Andrea Lessa Benedet, Tharick Pascoal, Sara Mohades, Sulantha Mathotaarachch, Laksanun Cheewakriengkrai, Monica Shin, Maxime Parent, Min Su Kang, Sarinporn Manitsirikul, Daliah Farajat, Seqian Wang, Jessica Di Ciero, Thomas Beaudry, Simon Eskildsen, Jared Rowley, Felix Carbonell, Vladmir Fonov, Serge Gauthier, Pedro Rosa-Neto, McGill Centre for Studies in Aging/Translational Neuroimaging Laboratory, Montreal, Quebec, Canada; Aarhus University, Aarhus, Denmark; Biospective Inc., Montreal, Quebec, Canada. Contact e-mail: lucaspschilling@gmail.com