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P4‐031: PLATELET APP RATIO IN AD PATIENTS TREATED WITH DONEPEZIL
Author(s) -
Sarno Tamires Alves,
Giroud Joaquim Helena Passarelli,
Talib Leda Leme,
Hototian Sergio,
Gattaz Wagner,
Forlenza Orestes Vicente
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1545
Subject(s) - donepezil , medicine , platelet , dementia , alzheimer's disease , amyloid precursor protein , disease , oncology
amyloid-b 40 with GAPDH aggregates revealed the significant pyramidal cell death and inflammation in the field of CA3, concomitant with the mitochondrial dysfunction. Conclusions: These findings suggest that GAPDH aggregates might act as a seed for amyloid-b 40 amyloidogenesis and enhances the cell death both in vitro and in vivo, providing a novel insight to investigate mechanisms underlying formation of amyloidal deposits such as senile and dendritic plaques in Alzheimer disease.