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P2–212: Morphometric analysis of the retina in a triple‐transgenic model of Alzheimer's disease
Author(s) -
Chiu Kin,
MoChing Leung Sara,
Yan Pui Leung Irene,
KaMing Lok Carmen,
Turner Raymond,
Matsuoka Yasuji,
So KwokFai,
ChuenChung Chang Raymond
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.858
Subject(s) - retina , tunel assay , retinal ganglion cell , pathology , genetically modified mouse , retinal , h&e stain , retinal degeneration , outer nuclear layer , biology , immunohistochemistry , inner nuclear layer , staining , congo red , transgene , ophthalmology , medicine , chemistry , neuroscience , genetics , gene , organic chemistry , adsorption
This journal suppl. contain abstracts of AAIC2013BACKGROUND: Reduction of retinal thickness has been reported in patients with mild cognitive impairment and Alzheimer's disease (AD). Recent studies reported Aβ accumulation, increase of TUNEL positive apoptotic bodies in the retinal ganglion cell (RGC) layer. However, morphometric analysis of RGC number and thickness of inner nuclear layer (INL) has not been characterized. We hypothesize that these two parameters can be served as biomarker to monitor degeneration in the retina of AD pathogenesis. Therefore, we aim to examine these two parameters in the retina of triple transgenic (3xTg) mic…link_to_OA_fulltex