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P1–399: BACE1 gene regulation: A novel drug target in Alzheimer's disease
Author(s) -
Bayon Baindu,
Lahiri Debomoy,
Bailey Jason
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.626
Subject(s) - amyloid precursor protein secretase , amyloid precursor protein , transfection , mechanism (biology) , alzheimer's disease , biology , microbiology and biotechnology , pharmacology , gene , disease , medicine , biochemistry , philosophy , epistemology
and perspective provided by an experienced researcher and investigator involved in a recently completed disease modifying immunotherapy program. Conclusions: It is imperative that methodological issues be identified and appropriately addressed in order to enhance the probability of success as the field moves forward into the long term investigation of earlier therapeutic interventions. We cannot afford to repeat the mistakes of the past.