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P4–125: Clinical characteristics of people with early‐onset Alzheimer's disease: A Clinical Research Center for Dementia of South Korea study
Author(s) -
Park Hee Kyung,
Park Sun A.,
Choi Seong,
Lee Yunhwan,
Han SeolHeui,
Kim EunJoo,
Kim BeoungChae,
Han Hyun Jeong,
Moon So,
Yang Dong Won,
Park Kyung Won,
Park Kee Hyung,
Yoon Bora,
Seo Sang Won,
Na Duk L.,
Na Hae Ri,
Lee JaeHong
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1515
Subject(s) - apathy , dementia , early onset alzheimer's disease , hyperintensity , medicine , neuropsychology , cohort , pediatrics , psychology , magnetic resonance imaging , cardiology , psychiatry , disease , cognition , radiology
Background: Patients with occipital dementia, post cortical atrophy, have all been to see the doctor in ophthalmic department for several years. And also they complain about the "memory disturbance "to neurologist. Theyhave special phenotype of neuropsycology and imaging. Methods: Use the step by step neurpsycological assessment, together with MRI (routine items T1.T2. FLARE AND GRE, resting state function MRI DTI VEM), FDG-PET. And follow up every 6months. Our dementia protocol (1) Detail and reliable Clinical history (the clinical course) from patient and caregivers. (2) Step by step neuropsychological assessment. (a)"screening" by MMSE, MOCA, and ADL, HAD. Second step———"system" assessment of neuropsychology (BATTERY modified by Chinese), memory, language, executive, visual space and construction, attention, calculation and judgment, each domain includes more than three items: for example, formemory we test BENTON test (type C method A), pared words association learning /AVLT, Episodic memory. (c)(If necessary) Special fields" assessment: aphasia, agnosia etc. (3) Detail exclusion tests: HBC, Vita B12, RPR, Thyroid function, HuYoRi, liver function. 3 DMRI are EEG necessary, if possible FDG-PET can be test. Results: 4 patients were diagnosed as occipital dementia, P.C.A.They all have been "treat" and operated in ophthalmic department for more than 5 years. They all complain memory disturbance. But the neuropsycological assessment prove the severe agnosia, memory relate reserve, oral language reserve, spatial agraphia. 2 of them have had the MRI and FDG PET. They show us dynamic atrophy of occipital lobe and parietal lobe. The FDG PET shows us dynamic changing not only on the occipital lobe but also on the parietal lobe and frontal lobe, the distributiong same like AD. The memory is relative reserve until 10 years.The network of memory is also reserved. Conclusions: Occipital lobe dementia has its own neuropsychological phenotype even though many reports prove it is one type of Alzheimer’s disease.