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P4–007: GWAS of rate of cognitive decline in four populations
Author(s) -
Sherva Richard,
Gross Alden,
Mukherjee Shubhabrata,
Crane Paul,
Newhouse Stephen,
Green Robert
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1395
Subject(s) - cognitive decline , cognition , genome wide association study , disease , episodic memory , single nucleotide polymorphism , gerontology , demography , psychology , dementia , medicine , genotype , biology , genetics , gene , neuroscience , sociology
Number of samples 26 6 5 7 8 Age at PET scan (years; mean6SD) 71.2767.49 72.67610.48 74.6065.41 71.4369.41 68.0062.73 4.59E-01 Education (years; mean6SD) 16.3562.78 16.5064.18 15.6063.58 16.5762.30 16.5061.69 9.39E-01 Gender (M/F) 9/17 2/4 4/1 2/5 1/7 9.38E-02 TSPO (Mixed/High) 9/17 1/5 4/1 1/6 3/5 8.17E-02 APOE (ε4-/ε4+ (%ε4+)) 15/11 (42.3) 3/3(50.0) 3/2(40.0) 5/2(28.6) 4/4(50.0) 8.27E-01 PBR_Thalamus (mean6SD) 1.5560.37 1.3860.48 1.2960.11 1.7860.31 1.6260.32 6.98E-02 PBR_Frontal (mean6SD) 1.4060.29 1.3560.34 1.1360.10 1.5860.25 1.4560.28 5.45E-02 PBR_Parietal (mean6SD) 1.3760.29 1.3460.34 1.1060.09 1.5260.26 1.4260.28 7.94E-02 PBR_Cingulate (mean6SD) 1.4460.32 1.3860.37 1.1560.10 1.6460.26 1.5060.30 4.32E-02 PBR_Temporal (mean6SD) 1.4160.28 1.3860.32 1.1660.08 1.5660.25 1.4560.27 7.89E-02 PBR_GlobalCtx_ plusCingSensMotor (mean6SD) 1.4060.30 1.3760.34 1.1360.09 1.5860.26 1.4560.28 6.63E-02