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P3–064: Characterizing the Alzheimer's disease prefrontal cortex transcriptome by multiple RNA‐sequencing
Author(s) -
Ryvkin Paul,
Leung Yuk Yee,
Dragomir Isabelle,
Schuck Theresa,
Schellenberg Gerard,
Arnold Steven,
ChenPlotkin Alice,
Van Deerlin Vivianna,
Lee Virginia,
Trojanowski John,
Gregory Brian,
Wang LiSan
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1134
Subject(s) - transcriptome , rna , biology , small nucleolar rna , microrna , ribosomal rna , small rna , transfer rna , non coding rna , computational biology , genetics , gene expression , gene
reprocessing. Transport mechanisms ferry cargoes over long distances along fragile highways, a process that appears inefficient and easily disrupted. In Alzheimer’s disease tau phosphorylation damages microtubules and axonal transport with disease propagation from entorhinal to other cortical regions and likely contributes to increased synaptic concentrations of aggregating amyloid beta (Braak H, et al. Curr Opin Neurol 2012;25:708). In the face of this vulnerable system, has evolutionary pressure generated better supply and waste management mechanisms?Results:Hypothesis Elaboration: Astrocytes far outnumber neurons and are principal candidates for this function. Astrocytic processes envelop neurons, make synaptic connections and act as intermediaries between blood and brain. Astrocytes may support neuronal networks through previously unappreciatedmechanisms, particularly local intercellular bidirectional exchange of organelles, RNA and other products essential for pre-synaptic integrity. This possibility is supported by t he recent discovery of organelle transfer between different cell types through tunneling nanotubes and in-vitro demonstration of nanotube connections between immature neurons and astrocytes (Abonunit S. J Cell Sci 2012;125:1089. Wang X et al. PLOS ONE 2012;7:e47429). Conclusions: Tunneling nanotubes and other intercellular transport mechanisms remain virtually unexplored in brain as potential local suppliers of essential products to protected neurons. Determination of the presence and nature of these mechanisms will be of great importance in understanding both normal brain function as well as contributions of the brain’s support system to the pathogenesis of Alzheimer’s disease.