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IC‐P‐080: Cross‐sectional clinical, neuropsychological, neuroimaging, neurophysiological and biochemical characterization of people with mild cognitive impairment in the WP5 PharmaCog/E‐ADNI study
Author(s) -
Babiloni Claudio,
BartrésFaz David,
Didic Mira,
Forloni Gianluigi,
Jovicich Jorge,
Nobili Flavio,
Payoux Pierre,
Schönknecht Peter,
Wiltfang Jens,
Blin Olivier,
Frisoni Giovanni
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.077
Subject(s) - neuroimaging , neuropsychology , psychology , cognitive impairment , medicine , neuropsychological assessment , cognition , biomarker , oncology , neuroscience , biochemistry , chemistry
A) Mean (sd) for sociodemographic and clinical scores. The groups are similar for all the considered variables. B) Follow-up information for clinical and imaging data. The average time of conversion for the 9 Ab+ and 6 Abwas not significantly different. C) Mean scores (sd) of longitudinal brain changes derived from the modeled trajectories. In addition to significantly higher Ab-induced scores, subjects Ab+ show also greater temporal atrophy rates. D) Association (p-values) between the interaction term Ab-induced*atrophy score and the longitudinal progression of neuropsychological scores (fitted in R: lm(neuropsywAb-induced*atrophy score))