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IC‐O1‐05: Structural differences in cognitively normal elderly individuals with abnormal amyloid biomarkers: Detection using volumetric MRI in ADNI and AIBL
Author(s) -
Gray Katherine R.,
Wolz Robin,
Heckemann Rolf A.,
Rueckert Daniel,
Hammers Alexander
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.020
Subject(s) - alzheimer's disease neuroimaging initiative , neuroimaging , medicine , disease , dementia , neurodegeneration , pittsburgh compound b , pathological , psychology , oncology , pathology , neuroscience
International audienceThe ability to identify individuals in the pre-symptomatic stages of Alzheimer's disease is desirable for early diagnosis, intervention and counselling, as well as drug discovery. Pathological changes in the brain precede cognitive symptoms by several years, and disease-specific biomarkers could potentially detect pre-clinical disease. So far, most efforts at early detection have focused on individuals already suffering from mild cognitive impairment, or have required serial imaging over 12 months. Here, we use volumetric MRI to identify early signs of neurodegeneration in baseline images of cognitively normal elderly individuals with evidence of cortical β-amyloid deposition