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P1‐134: Inhibition of PARP‐1 attenuates tau phosphorylation by regulation of glycogen synthase kinase‐3
Author(s) -
Shigeo Murayama,
Yuko Saito,
Tamao Tsukie,
Yasuo Ihara,
Ryozo Kuwano
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.414
Subject(s) - gsk 3 , gsk3b , glycogen synthase , phosphorylation , poly adp ribose polymerase , atp synthase , chemistry , microbiology and biotechnology , kinase , enzyme , biology , biochemistry , polymerase
pound for potential utility in the treatment of a disorder that is associated with mitochondrial defects. Preclinical diagnosis of Alzheimer’s disease (AD) is one of the major challenges for the prevention of AD. AD biomarkers are needed not only to reveal preclinical pathologic changes, but also to track the course of the disease, and monitor response to treatments. Methods: Changes in the brain in Alzheimer’s Disease begins as many as 10 to 30 years before any problems are evident. The concept of primary prevention derives from the knowledge that Alzheimer’s disease (AD) develops over decades and has a prolonged asymptomatic phase during which it is possible to modify the course of disease. Thus, earlier detection of metabolically significant and “subclinical” or “preclinical” AD may allow for more timely intervention that in turn may prevent progression to and symptomatic illness, that is characterized by loss and/or atrophy of neurons in discrete regions of the brain, and that is accompanied by extracellular proteolysis and deposits of beta-amyloid and the intracellular accumulation of neurofibrillary tangles. Results: Stabilization of protein prenylation and gene stabilization model proposed in this research combines the continuous aspects of gene regulation in a simple and structured way and led to new results and the comprehension of preclinical diagnosis of Alzheimer’s disease (AD). Thus, isoprene biogenesis coupled with isopentenyl tRNAs biosynthesis relays provides an efficient energetic unit in support of mitochondrial energy metabolism and nuclear transport.