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O2‐06‐03: Effects of hypertension on cognitive decline: Mediation by exposure duration, antihypertensive treatment and APOE‐e4 genotype
Author(s) -
Baars Lia M.A.E.,
Boxtel Martin P.J.,
Tan Frans S.,
Bekers Otto,
Verhey Frans R.J.,
Jolles Jelle
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.340
Subject(s) - cognitive decline , dementia , cognition , blood pressure , medicine , diabetes mellitus , effects of sleep deprivation on cognitive performance , population , neuropsychology , psychology , psychiatry , endocrinology , disease , environmental health
apolipoprotein e4 status and a number of midlife health and lifestyle indicators, including blood pressure, cholesterol and marital status. Results: Depressive signs in midlife, as measured in this study, were significantly related to general cognitive impairment in later life, but also separately to both mild cognitive impairment and Alzheimer’s disease. When dichotomized into high versus low levels of depressive signs the odds ratios were 2.19 (1.1 to 4.3) for mild cognitive impairment and 3.81 (1.3 to 11.5) for Alzheimer’s disease. Significant associations were also found between the separate measures of hopelessness and loneliness on the one hand and the separate outcomes of mild cognitive impairment and Alzheimer’s disease on the other. Conclusions: The results support a causal relation between depressive signs relatively early in life and cognitive function in later life. Clinical relevance includes the long-term health implications of depressive signs in midlife also for the risk of dementia.