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P3‐313: Using single‐point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β‐site APP cleaving enzyme 1 (BACE1)
Author(s) -
Lu Yasong,
Liu Jianhua,
Nelson Frederick,
Ambroise Claude,
Fisher Katherine,
Hajos-Korcsok Eva,
Noell Stephen,
Nolan Charles E.,
Oborski Christine E.,
Lanyon Lorraine F.,
Christoffersen Curt,
Hannah Divine,
Efremov Ivan,
Helal Chris,
Brodney Michael A.,
O'Neill Brian T.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1814
Subject(s) - ivivc , potency , in vivo , in vitro , pharmacology , chemistry , ic50 , drug discovery , pharmacodynamics , pharmacokinetics , biochemistry , medicine , biology , biopharmaceutics classification system , dissolution testing , microbiology and biotechnology