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P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APP swe/ind mice
Author(s) -
Hyde Lynn A.,
Del Vecchio Robert A.,
Kazdoba Tatiana M.,
Manning Ronald,
Terracina Giuseppe,
Zhang Qi,
Babu Suresh,
Guo Tao,
Tadese Dawit,
Zhang Lili,
Parker Eric M.,
Stamford Andrew W.,
Kennedy Matthew E.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1799
Subject(s) - genetically modified mouse , senile plaques , amyloid precursor protein , pharmacology , amyloid precursor protein secretase , chemistry , transgene , alzheimer's disease , cognitive decline , amyloid (mycology) , biochemistry , medicine , pathology , disease , dementia , gene