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P3‐182: Identification of target engagement biomarkers for MARK inhibitor discovery using quantitative mass spectrometry
Author(s) -
Hayashi Mansuo,
Paweletz Cloud,
Yu Shang-Shuan,
Nuthall Hugh,
Northrup Alan,
Chi An,
Hendrickson Ron
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1680
Subject(s) - autophosphorylation , stable isotope labeling by amino acids in cell culture , phosphorylation , kinase , biochemistry , chemistry , serine , biology , phosphoproteomics , protein phosphorylation , proteomics , microbiology and biotechnology , protein kinase a , gene
decrease in intracellular vitamin E was associated with the deterioration in cognitive performance. The correlation between oxidative changes and mitochondral dysfunction will be established. Conclusions: These results suggest that accumulation of oxidative damage may start in pre-symptomatic phases of AD pathology and that progression to AD might be related to deplection of antioxidant defenses. This work was supported by the Portuguese Foundation for Science and Technology (FCT) through PIC/ IC/83206/2007