Premium
P2‐422: Increased functional integration of the medial temporal lobe in patients with Alzheimer's disease
Author(s) -
Dhanjal Novraj S.,
Leech Robert,
Morales Jose,
Beckmann Christian,
Wise Richard J.S.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1475
Subject(s) - episodic memory , functional magnetic resonance imaging , temporal lobe , psychology , entorhinal cortex , neuroscience , audiology , default mode network , amnesia , cognition , hippocampus , cognitive psychology , medicine , epilepsy
lateral temporo-parietal cortex,whereasMCI patients showed a significant increase only in bilateral precuneus. Conclusions: The present fMRI study demonstrates that neural mechanisms supporting recognition of personal familiarity are altered in patients with amnestic MCI when compared to healthy elderly control subjects and that there is a loss of the differential activation of a specific network underlying personal familiarity.