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P4‐106: Association study about genetic variants of inflammation‐linked genes and dementia in the very old: The Monzino 80‐plus Study
Author(s) -
Albani Diego,
Batelli Sara,
Polito Letizia,
Dusi Sabrina,
Tettamanti Mauro,
Lucca Ugo,
Forloni Gianluigi,
Negri Mario
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.774
Subject(s) - single nucleotide polymorphism , dementia , genotyping , snp , population , medicine , disease , genotype , genetics , biology , gene , environmental health
(p<0.02). To study ESR1-APOE gene-gene interactions and sexual dimorphism of selected markers, we stratified our series according to APOE genotype and grouping AD cases and controls in accordance with gender or APOE genotypes. A weak evidence of genetic interaction was observed between APOE genotypes and ESR1 markers. In contrast sexual dimorphism was evident for ESR1 rs3844508 marker effect which appeared stronger in males (OR1⁄41.75 [C.I.1.27