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P1‐180: Relationship between patient dependence on others and caregiver burden in Alzheimer's Disease (AD)
Author(s) -
Lacey Loretto A.,
McLaughlin Trent P.,
Mucha Lisa,
Grundman Michael,
Black Ron
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.186
Subject(s) - caregiver burden , multivariate analysis , psychology , univariate analysis , disease , cognition , alzheimer's disease , clinical psychology , medicine , gerontology , psychiatry , dementia
ADRDA criteria. Cognitive functions were assessed using K-MMSE , KCDR and Seoul Neuropsychological Screening Battery. The frequency and severity of NPS were evaluated with of K-NPI. MRI or PET-CT of brain was applied to all patients. In general AD was classified as mild, moderate, severe and the corresponding K-MMSE scores are 20-24, 10-19, 0-9, the CDR scores are 0.5-1, 2-3, 4-5 But these are too wide range of scores in each group that might prevent which symptoms are frequent in exact phase or severity of disease, so we try to more subdivide into 6 groups, I(0-5), II(69), III (10-14), IV(15-19), V(20-24), VI (25<) in K-MMSE and I(0.5) , II(1), III (2), IV (3), V (4), VI (5) in CDR. We also evaluate correlation between ADL , Instrumental ADL and NPS. Results: Elation, euphoria were dominant in group IV in K-MMSE and group II in CDR. Delusion, apathy, indifference, aberrant motor behavior, sleep, night time behavior, appetite, eating change were high in group II in K-MMSE & III in CDR. Hallucination, agitation, aggression, depression, anxiety, disinhibition, irritability was frequent in group I in K-MMES & IV in CDR. Delusion, hallucination, disinhibition were high correlated with K-MMSE (p<0.05). Halluciantion, depression, dysphoria, disinhibition, irritability and aberrant behaviour were well related with CDR (p<0.05). Not only Barthel index was highly correlation with anxiety (r1⁄40.96), aberrant behavior (r1⁄40.86) but also instrumental ADL was related to CDR (r1⁄40.72). Conclusions: Although more than half of AD patients who visited to memory clinic are in mild stage of dementia, most of NPS of AD were common in group I & II in K-MMSE and III, IV in CDR except elation & euphoria. Subdivision of AD patient’s stage shows more detail status of NPI than previous reports.