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P1‐222: In vivo proton MRS biomarkers of geriatric Rhesus monkey brain show the gliosis and neuronal degeneration characteristic of human Alzheimer's disease
Author(s) -
Blenman RoseAnn M.,
Holahan Marie,
Welsh Denise,
Cook Jacquelynn,
Hargreaves Richard,
Williams Donald S.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.811
Subject(s) - gliosis , medicine , pathology , human brain , alzheimer's disease , physiology , disease , neuroscience , psychology , psychiatry
three or more times with a follow-up of at least one year were selected resulting in 120 subjects with two scans and a clinical/pathological diagnosis (Table 1). Subjects’ scans were reviewed as a single first scan (method 1), the two unregistered presented side-by-side (method 2), and the registered pair (method 3). Separate assessments were made by a neuro-radiologist and a clinician. For each method each reviewer had to make both a main and a specific (subtype) diagnosis.