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P4‐218: Functional role of BACE1 and presenilin‐1 interaction
Author(s) -
Levesque Georges,
Hebert Sebastien,
Christian Lessard,
Brault Marie Eve
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2286
Subject(s) - presenilin , nicastrin , amyloid precursor protein , mutant , immunoprecipitation , amyloid precursor protein secretase , mutation , chemistry , microbiology and biotechnology , neurodegeneration , biology , biochemistry , alzheimer's disease , gene , medicine , disease
mock-transduced cells without affecting the levels of full-length APP. Secreted A -40 and -42 levels in the conditioned media from p120transduced cell culture were significantly reduced compared to those from mock-transduced cells. Conclusions: Protein p120 stimulates the PS/ secretase processing of cadherins but inhibits the same kind of processing of APP thus reducing production of A peptides.