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P4‐217: Regulated intramembrane proteolysis of tumour necrosis factor receptor 1 (TNFR 1)
Author(s) -
Harte Frances M.,
Elzinga Baukje M.,
McCarthy Justin V.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2285
Subject(s) - presenilin , amyloid precursor protein secretase , amyloid precursor protein , microbiology and biotechnology , alpha secretase , biology , proteolysis , biochemistry , chemistry , alzheimer's disease , medicine , disease , pathology , enzyme
mock-transduced cells without affecting the levels of full-length APP. Secreted A -40 and -42 levels in the conditioned media from p120transduced cell culture were significantly reduced compared to those from mock-transduced cells. Conclusions: Protein p120 stimulates the PS/ secretase processing of cadherins but inhibits the same kind of processing of APP thus reducing production of A peptides.