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P3‐002: Are the specialists doing enough? A register‐based nationwide evaluation of clinical dementia practice in the secondary health care sector
Author(s) -
Andersen Birgitte Bo,
Phung Kieu T.T.,
Kessing Lars V.,
Mortensen Preben B.,
Waldemar Gunhild
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1565
Subject(s) - dementia , medicine , medical diagnosis , referral , medical record , disease , vascular dementia , family medicine , population , pediatrics , environmental health , pathology
to the inhibitor structure, as well as filling extra binding pockets with additional functional groups. The optimised lead was shown to have enhanced activity with an IC50 towards BACE1 of 37 M. Analogues with IC50 100 M towards BACE1 were tested in the cellular assay, and selected compounds have shown promising cellular activity with EC50 10 M. Conclusions: The rational design approach using de novo design software SPROUT has successfully delivered a new cellular active BACE1 inhibitor scaffold.