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P2‐138: Prevention of tau aggregation in vitro and in cells by low molecular weight compounds derived from phenylthiazolyl‐hydrazide or rhodanine core structures
Author(s) -
Pickhardt Marcus,
Bulic Bruno,
Larbig Gregor,
Coksezen Atilla,
Biernat Jacek,
Khlistunova Inna,
Mandelkow Eva-Maria,
Schmidt Boris,
Waldmann Herbert,
Meyer Bernd,
Mandelkow Eckhard
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1211
Subject(s) - hydrazide , chemistry , rhodanine , tau protein , in vitro , biophysics , lipophilicity , ic50 , viability assay , combinatorial chemistry , biochemistry , alzheimer's disease , biology , organic chemistry , medicine , disease , pathology
Marcus Pickhardt, Bruno Bulic, Gregor Larbig, Atilla Coksezen, Jacek Biernat, Inna Khlistunova, Eva-Maria Mandelkow, Boris Schmidt, Herbert Waldmann, Bernd Meyer, Eckhard Mandelkow, Max-Planck-Institute, Dept. of Structural Molecular Biology, Hamburg, Germany; Max-Planck-Institute for Molecular Physiology, Dortumnd, Germany; Institute of Organic Chemistry, Technical University of Darmstad, Darmstad, Germany; Institute for Organic Chemistry, University of Hamburg, Hamburg, Germany; Institute of Organic Chemistry, Technical University of Darmstadt, Darmstadt, Germany; Max-Planck-Institute for Molecular Physiology, Dortmund, Dortmund, Germany. Contact e-mail: Pickhardt@mpasmb.desy.de