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O3–04–02: Cognitive impairment and metabolic syndrome in Mexico: A common origin in synergic factors acting from early childhood
Author(s) -
Gutierrez-Robledo Luis Miguel,
Mejia Silvia,
Villa Antonio,
Ruiz-Arregui Liliana,
Dartigues Jean Francois
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.215
Subject(s) - medicine , socioeconomic status , anthropometry , dementia , context (archaeology) , obesity , gerontology , cognition , diabetes mellitus , demography , population , cognitive decline , pediatrics , environmental health , psychiatry , disease , geography , endocrinology , archaeology , sociology
found them to be reduced in PS1(n-/-) mice while increased in PS1[A246E] mice. These biochemical findings correlate with decreased and increased levels of nuclear c-Fos in PS1(n-/-) mice and PS1[A246E] mice, respectively. Finally, while PS1[A246E] and PS1(n-/-) mice both performed normally in object recognition and spatial navigation tasks, the PS1[A246E] mice displayed improved contextual fear conditioning, in contrast to a subtle impairment in PS1(n-/-) mice in this task. Conclusion: Our data demonstrate both preand postsynaptic roles for wild-type PS1 in synaptic plasticity, while mutant PS1[A246E] acts post-synaptically and opposite to PS1-deficiency.
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