Premium
[O2‐03‐08]: Community of caring: A continuum of normalized evidence‐based programs to maintain function
Author(s) -
Buettner Linda L.,
Fitzsimmons Suzanne
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.349
Subject(s) - recreation , dementia , toolbox , cognition , psychology , service (business) , intervention (counseling) , gerontology , medical education , nursing , medicine , psychiatry , engineering , business , political science , marketing , disease , mechanical engineering , pathology , law
ization time of flight MS, and conclusive protein identifications accomplished by liquid chromatography-tandem MS. Conclusions: Several proteins were reproducibly quantitatively affected by GSE in rat brain, either in abundance, or in isoform complexity. The majority were “old” proteins, i.e. those that had been shown to be differentially expressed in AD or transgenic mouse models of dementia (i.e. creatine kinase brain beta chain, glial fibrillary acidic protein). Because the direction of change for most proteins affected by GSE in the normal healthy rats was opposite to that in AD or transgenic demented mouse brain, administration of GSE to healthy adults to protect critical proteins may be a strategy for prevention of AD.