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Cytoplasmic dynein/dynactin function and dysfunction in motor neurons
Author(s) -
Levy Jennifer R.,
Holzbaur Erika L.F.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2005.11.013
Subject(s) - dynactin , dynein , microtubule , microbiology and biotechnology , axoplasmic transport , biology , motor protein , vesicular transport protein , motor neuron , neuroscience , chemistry , biochemistry , vesicle , spinal cord , membrane
The microtubule motor protein cytoplasmic dynein and its activator dynactin are essential in higher eukaryotes, due to critical roles in vesicular transport and cell division. Neurons are uniquely sensitive to defects in dynein/dynactin function, which affect retrograde axonal transport, neurotrophic factor signaling, neurofilament transport, mRNA localization, neuronal migration, and protein recycling and degradation. Mutations in either dynein or dynactin lead to motor neuron degeneration and loss. Recent progress in understanding the cellular mechanisms of dynein/dynactin function, and the effects of dynein/dynactin dysfunction has provided new insight into the roles of microtubule‐based motility in the neuron.
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