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Regulation of SIRT1 protein levels by nutrient availability
Author(s) -
Kanfi Yariv,
Peshti Victoria,
Gozlan Yosi M.,
Rathaus Moran,
Gil Reuven,
Cohen Haim Y.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.06.005
Subject(s) - sirtuin 1 , nutrient , nad+ kinase , calorie restriction , homeostasis , nutrient sensing , microbiology and biotechnology , biology , calorie , messenger rna , biochemistry , chemistry , endocrinology , downregulation and upregulation , enzyme , signal transduction , ecology , gene
The mammalian NAD+ dependent deacetylase, SIRT1, was shown to be a key protein in regulating glucose homeostasis, and was implicated in the response to calorie restriction. We show here that levels of SIRT1 increased in response to nutrient deprivation in cultured cells, and in multiple tissues of mice after fasting. The increase in SIRT1 levels was due to stabilization of SIRT1 protein, and not an increase in SIRT1 mRNA. In addition, p53 negatively regulated SIRT1 levels under normal growth conditions and is also required for the elevation of SIRT1 under limited nutrient conditions. These results have important implications on the relationship between sirtuins, nutrient availability and aging.
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