Crucial role of peroxiredoxin III in placental antioxidant defense of mice | Zendy

Li Lianqin | Zendy; Shoji Wataru | Zendy; Oshima Hiroaki | Zendy; Obinata Masuo | Zendy; Fukumoto Manabu | Zendy; Kanno Naoko | Zendy

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Crucial role of peroxiredoxin III in placental antioxidant defense of mice

Author(s) -

Li Lianqin,

Shoji Wataru,

Oshima Hiroaki,

Obinata Masuo,

Fukumoto Manabu,

Kanno Naoko

Publication year - 2008

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.05.050

Subject(s) - knockout mouse , peroxiredoxin , oxidative stress , western blot , fetus , andrology , antioxidant , biology , placenta , immunology , pregnancy , microbiology and biotechnology , endocrinology , medicine , genetics , biochemistry , receptor , gene , peroxidase , enzyme

We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT‐PCR) and Western‐blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild‐type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up‐regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage.

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