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Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
Author(s) -
Alcaino Hernan,
Greig Douglas,
Chiong Mario,
Verdejo Hugo,
Miranda Rodrigo,
Concepcion Roberto,
Vukasovic José Luis,
DiazAraya Guillermo,
Mellado Rosemarie,
Garcia Lorena,
Salas Daniela,
Gonzalez Leticia,
Godoy Ivan,
Castro Pablo,
Lavandero Sergio
Publication year - 2008
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2008.05.008
Subject(s) - uric acid , heart failure , medicine , superoxide dismutase , endothelial dysfunction , endocrinology , ejection fraction , endothelium , superoxide , extracellular , oxidative stress , biochemistry , enzyme , chemistry
Abstract Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty‐eight chronic heart failure patients (New York Heart Association functional class II–III, mean age 58±10 years and mean left ventricular ejection fraction 25±8%) and twelve age‐and‐sex‐matched healthy controls were studied. Chronic heart failure patients showed higher uric acid levels (7.3±2.3 mg/dL vs. 6.1±0.2 mg/dL, p <0.05) and lower extracellular superoxide dismutase activity (136±36 U ml −1 min −1 vs. 203±61 U ml −1 min −1 , p <0.01) and endothelium‐dependent vasodilatation (4.0±1.6% v. 9.1±3.0%, p <0.01) when compared with control subjects. In chronic heart failure patients, correlations between both uric acid levels and extracellular superoxide dismutase activity ( r =0.45; p <0.01), and uric acid and endothelium‐dependent vasodilatation ( r =0.35; p =0.03) were detected. These correlations were not observed in healthy individuals, suggesting a positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure.