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Serial monitoring of serum estradiol and progesterone levels during the HMG‐HCG therapy in six anovulatory women
Author(s) -
Sakuragi Noriaki,
Tanaka Toshinobu,
Fujimoto Seiichiro,
Ichinoe Kihyoe
Publication year - 1981
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(81)90038-2
Subject(s) - medicine , hmg coa reductase , endocrine system , gonadotropin , menotropins , endocrinology , gynecology , ovulation , hormone , ovulation induction , biochemistry , reductase , enzyme , chemistry
Abstract Serum estradiol (E 2 ) and progesterone (P) levels were radioimmunoassayed every or every other day for monitoring the HMG‐HCG therapy in six anovulatory patients, and the clinical significance of measuring steroid hormones as precautionary counter‐plot against the ovarian hyperstimulation syndrome and multiple pregnancies was evaluated. Administration of HCG is recommended to trigger ovulation when serum E 2 levels reach 400–600 pg/ml. Mean peak P level in 7–8 days after ovulation induced by HMG‐HCG was 22.9 ng/ml, which is significantly higher than P levels of the same period in spontaneous and clomiphene‐induced ovulations. This result suggests that there may occur multiple ovulations which result in multiple pregnancies in HMG‐HCG therapy.