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A benzothiophene‐carboxamide is a potent inhibitor of IL‐1β induced VCAM‐1 gene expression in human endothelial cells
Author(s) -
Cobb Ronald R.,
Felts Katherine A.,
McKenzie Thomas C.,
Parry Graham C.N.,
Mackman Nigel
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00202-5
Subject(s) - vcam 1 , cell adhesion molecule , benzothiophene , endothelial stem cell , cytokine , chemistry , microbiology and biotechnology , cell adhesion , icam 1 , biology , cell , immunology , in vitro , biochemistry , thiophene , organic chemistry
Vascular endothelial cells respond to cytokines such as IL‐1β or TNF‐α by undergoing a number of functional alterations. Among these alterations is the induction of cell surface adhesion molecules, including VCAM‐1. In this report, we investigated the effects of a 3‐alkoxybenzo[β]thiopene‐2‐carboximide (BZT) on the cytokine induction of VCAM‐1 expression and activation of the transcription factor NF‐κB in human endothelial cells. BZT blocked the IL‐1β induced cell surface expression of VCAM‐1 in human endothelial cells but did not prevent nuclear translocation of NF‐κB. This study demonstrates that BZT is a potent inhibitor of VCAM‐1 expression in human endothelial cells.