Ascorbate synthesis‐dependent glutathione consumption in mouse liver | Zendy

Bánhegyi Gábor | Zendy; Csala Miklós | Zendy; Braun László | Zendy; Garzó Tamás | Zendy; Mandl József | Zendy

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Ascorbate synthesis‐dependent glutathione consumption in mouse liver

Author(s) -

Bánhegyi Gábor,

Csala Miklós,

Braun László,

Garzó Tamás,

Mandl József

Publication year - 1996

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/0014-5793(96)00077-4

Subject(s) - glutathione , chemistry , catalase , hydrogen peroxide , biochemistry , microsome , antioxidant , ascorbic acid , medicine , endocrinology , biology , enzyme , food science

Ascorbate synthesis causes glutathione consumption in the liver. Addition of gulonolactone resulted in an increase of ascorbate production in isolated murine hepatocytes. At the same time, a decrease in reduced glutathione (GSH) level was observed. In hepatic microsomal membranes, ascorbate synthesis stimulated by gulonolactone caused an almost equimolar consumption of GSH. This effect could be counteracted by the addition of catalase or mercaptosuccinate, indicating the role of hydrogen peroxide formed during ascorbate synthesis in the depletion of GSH. The observed phenomenon may be one of the reasons why the evolutionary loss of ascorbate synthesis could be advantageous.

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