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Identification of a member of mouse semaphorin family
Author(s) -
Shinobu Inagaki,
Tatsuo Furuyama,
Yoshiko Iwahashi
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00850-9
Subject(s) - semaphorin , transmembrane protein , plexin , axon guidance , biology , transmembrane domain , microbiology and biotechnology , immunoglobulin domain , gene , neuropilin , genetics , axon , receptor , neuropilin 1 , vascular endothelial growth factor , cancer research , vegf receptors
Grasshopper semaphorin I (Sema I) and its related proteins, chick collapsin and mouse Sema III contribute to the axon guidance by their repellent actions [5,9,12]. We have identified a member of semaphorin gene family from the mouse brain and named it M‐Sema F. The N‐terminal encodes a semaphorin domain that is similar between Sema I–III [6] followed by a single putative immunoglobulin‐like domain, a transmembrane domain, and a proline‐rich intracellular domain. M‐Sema F mRNA is expressed widely in the nervous tissues during development. These suggest that M‐Sema F is a transmembrane member of the semaphorin family of the vertebrate which may function in the developing neuronal network.