Plasma 8‐epi‐PGF 2α  levels are elevated in individuals with non‐insulin dependent diabetes mellitus | Zendy

Gopaul N.K. | Zendy; Änggård E.E. | Zendy; Mallet A.I. | Zendy; Betteridge D.J. | Zendy; Wolff S.P. | Zendy; Nourooz-Zadeh J. | Zendy

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Plasma 8‐epi‐PGF 2α levels are elevated in individuals with non‐insulin dependent diabetes mellitus

Author(s) -

Gopaul N.K.,

Änggård E.E.,

Mallet A.I.,

Betteridge D.J.,

Wolff S.P.,

Nourooz-Zadeh J.

Publication year - 1995

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/0014-5793(95)00649-t

Subject(s) - medicine , endocrinology , lipid peroxidation , chemistry , diabetes mellitus , oxidative stress , arachidonic acid , insulin , in vivo , biochemistry , biology , enzyme , microbiology and biotechnology

This study reports plasma levels of a specific nonenzymatic peroxidation product of arachidonic acid, esterified 8‐epi‐PGF 2α , from healthy‐ and NIDDM individuals as an index of oxidative stress in vivo. Plasma 8‐epi‐PGF 2α was isolated by solid‐phase extraction on a C,8 followed by an NH 2 cartridge and analyzed by GC‐MS/NICI as PFB‐ester/TMS‐ether derivative. We found that the average concentration of esterified 8‐epi‐PGF 2α among NIDDM subjects (0.93 ± 0.07 nM, n = 39) was higher ( P < 0.0001, Mann‐Whitney test) than in healthy individuals (0.28 ± 0.04 nM, n = 15). These data indicate that NIDDM is associated with increased plasma lipid peroxidation.

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