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Expression of α 2 ‐macroglobulin receptor/low density lipoprotein receptor‐related protein is increased in reactive and neoplastic glial cells
Author(s) -
Lopes M.Beatriz S.,
Bogaev Christopher A.,
Gonias Steven L.,
VandenBerg Scott R.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80288-2
Subject(s) - alpha 2 macroglobulin , receptor , ldl receptor , lrp1 , biology , alpha (finance) , lipoprotein , immunohistochemistry , neoplastic transformation , chemistry , microbiology and biotechnology , macroglobulin , endocrinology , biochemistry , immunology , medicine , gene , cholesterol , carcinogenesis , construct validity , nursing , patient satisfaction
α 2 ‐Macroglobulin receptor/low density lipoprotein receptor‐related protein (α 2 M‐R/LRP) is a multi‐functional cell‐surface receptor that has been implicated in diverse physiologic processes. In normal human brain, α 2 M‐R/LRP is expressed principally by pyramidal neurons with localization to cell bodies and proximal processes. By contrast, α 2 M‐R/LRP is not present in either the cell bodies or processes of most normal macroglia (including astrocytes). In this investigation, we studied the expression of α 2 M‐R/LRP in the brain, following tissue injury or neoplastic transformation, by immunohistochemistry. Significantly increased α 2 M‐R/LRP immunoreactivity was identified in reactive astrocytes, indicating that expression of this receptor is regulated in vivo in response to brain injury. α 2 M‐R/LRP immunoreactivity was also detected in glial cell tumors; this finding is novel since malignant transformation is typically thought to turn off expression of this receptor.