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Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol‐10 and polyunsaturated fatty acid content
Author(s) -
Kontush Anatol,
Hubner Christoph,
Finckh Barbara,
Kohlschutter Alfried,
Beisiegel Ulrike
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80242-4
Subject(s) - ubiquinol , chemistry , polyunsaturated fatty acid , copper , food science , fatty acid , biochemistry , low density lipoprotein , organic chemistry , cholesterol , apoptosis , cytochrome c , coenzyme q – cytochrome c reductase
At an early stage of oxidation induced by Cu 2+ , the rate of oxidative modification of human low density lipoprotein (LDL) from healthy donors correlated negatively to its ubiquinol‐10 ( r = −0.58, P < 0.01) and positively to its polyunsaturated fatty acid (PUFA) ( r = 0.53, P < 0.05) content. The PUFA/ubiquinol‐10 ratio was the best predictor of LDL susceptibility to oxidation ( r = 0.68, P < 0.01). No significant correlation between LDL oxidizability and its α‐tocopherol content was found at any oxidation stage. It is suggested that ubiquinol‐10 plays a central role in the early protection of LDL PUFAs against Cu 2+ ‐induced oxidation whereas α‐tocopherol posesses both pro‐ and antioxidant activity.